Symbol
Name
ID

Cd4
CD4 antigen
MGI:88335

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased proportion of CD4-positive T cells	Recurrent upper respiratory tract infections	Recurrent otitis media
Disease(s) Associated with CD4
immunodeficiency 79

Mouse Phenotypes

immune system phenotype

increased T cell apoptosis

decreased T cell proliferation

increased T cell proliferation

abnormal T cell differentiation

abnormal double-positive T cell morphology

decreased double-positive T cell number

absent plasma cells

decreased CD4-positive, alpha-beta T cell number

absent CD4-positive, alpha-beta T cells

increased CD8-positive, alpha-beta T cell number

decreased T cell number

abnormal CD4-positive, alpha beta T cell morphology

abnormal spleen morphology

decreased IgG level

decreased IgM level

decreased immunoglobulin level

abnormal CD4-positive, alpha-beta T cell physiology

abnormal T-helper 2 physiology

abnormal regulatory T cell physiology

abnormal immune system organ morphology

abnormal lymph node T cell domain morphology

impaired humoral immune response

abnormal interleukin-4 secretion

decreased susceptibility to autoimmune diabetes

brain inflammation

increased susceptibility to parasitic infection

increased susceptibility to Picornaviridae infection

Availability

Mouse Genotype

Cd4^del/Cd4^del

Cd4^em1Litt/Cd4^em1Litt

Cd4^m1Btlr/Cd4^m1Btlr

Cd4^maat/Cd4^maat

Cd4^sesh/Cd4^sesh

Cd4^thth/Cd4^thth

Cd4^tm1Jrp/Cd4^tm1Jrp

Cd4^tm1Knw/Cd4^tm1Knw

Cd4^tm1Litt/Cd4^tm1Litt

Cd4^tm1Mak/Cd4^tm1Mak

Cd4^tm1Nik/Cd4^tm1Nik
Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺ (conditional)

Cd4^tm1Litt/Cd4^tm1Nik
Tg(Lck-cre)3778Nik/0 (conditional)

Cd4^tm1Litt/Cd4^tm1Nik
Tg(Lck-icre)3779Nik/0 (conditional)

Cd4^tm1Litt/Cd4^tm1Nik
Tg(Lck-cre)3785Nik/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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